Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification

…, G Gaviraghi, E Genesio, C Ghiron, L Magnoni…

Index: Cocconcelli, Giuseppe; Diodato, Enrica; Caricasole, Andrea; Gaviraghi, Giovanni; Genesio, Eva; Ghiron, Chiara; Magnoni, Letizia; Pecchioli, Elena; Plazzi, Pier Vincenzo; Terstappen, Georg C. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 4 p. 2043 - 2052

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Citation Number: 24

Abstract

A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in an in vitro assay using a NMDA toxicity paradigm showing a neuroprotective activity between 15% and 40%. The potential biological target of the active compounds was investigated by extensive literature searches based around similar scaffolds with reported neuroprotective activity. The most interesting molecules active in ...

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