Synthesis of non-natural cyclic amino acids from available unsaturated tertiary amines

ID Titanyuk, IP Beletskaya

Index: Titanyuk; Beletskaya Russian Journal of Organic Chemistry, 2010 , vol. 46, # 9 p. 1277 - 1281

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Citation Number: 4

Abstract

Abstract New approach is developed to the synthesis of cyclic amino acids derivatives. Unsaturated tertiary amines react with ethyl diazoacetate under the catalysis by copper catalyst Cu (F 3 acac) 2 leading to the formation of products of [2, 3]-sigmatropic rearrangement which via the metathesis of double bonds undergo a ring closure. The subsequent hydrogenation of compounds obtained furnished esters of 6-and 7-membered ...