Planta Medica 1989-08-01

Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.

A De Bruyn, M Verzele, J P Dejonghe, K S Bhushana Rao, M P Collard, A Trouet, J Hannart

Index: Planta Med. 55(4) , 364-6, (1989)

Full Text: HTML

Abstract

A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.

Related Compounds

  • 4-Desacetylvinblas...

Related Articles:

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography.

1993-01-01

[Cancer Chemother. Pharmacol. 32(4) , 286-92, (1993)]

Disposition of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-desacetylvinblastine in tumor-bearing nude mice.

1987-05-01

[J. Pharmacol. Exp. Ther. 241(2) , 695-703, (1987)]

Quantitation of human anti-mouse antibody in serum by flow cytometry.

1992-01-01

[Cytometry 13(3) , 275-81, (1992)]

High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolite 4-O-deacetylvinblastine-3-oic acid in biological fluids.

[J. Chromatogr. A. 553(1-2) , 47-53, (1991)]

More Articles...