ChemBioChem 2015-08-17

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA.

Naoki Umezawa, Yuhei Horai, Yuki Imamura, Makoto Kawakubo, Mariko Nakahira, Nobuki Kato, Akira Muramatsu, Yuko Yoshikawa, Kenichi Yoshikawa, Tsunehiko Higuchi

Index: ChemBioChem. 16 , 1811-9, (2015)

Full Text: HTML

Abstract

A versatile solid-phase approach based on peptide chemistry was used to construct four classes of structurally diverse polyamines with modified backbones: linear, partially constrained, branched, and cyclic. Their effects on DNA duplex stability and structure were examined. The polyamines showed distinct activities, thus highlighting the importance of polyamine backbone structure. Interestingly, the rank order of polyamine ability for DNA compaction was different to that for their effects on circular dichroism and melting temperature, thus indicating that these polyamines have distinct effects on secondary and higher-order structures of DNA. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Related Compounds

  • mercaptoethanol
  • 3-(4-Methoxyphenyl...

Related Articles:

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

2015-04-15

[Biochem. J. 467(2) , 345-52, (2015)]

Effect of (2)H and (18)O water isotopes in kinesin-1 gliding assay.

2014-01-01

[PeerJ 2 , e284, (2014)]

Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.

2014-07-07

[Mol. Pharm. 11(7) , 1991-6, (2014)]

Long-chain fatty acid analogues suppress breast tumorigenesis and progression.

2014-12-01

[Cancer Res. 74(23) , 6991-7002, (2014)]

Anaphylaxis induced by a drug containing lysozyme and papain: influence of papain on the IgE response.

2014-01-01

[Int. Arch. Allergy Immunol. 165(2) , 83-90, (2014)]

More Articles...