Microbios 1993-01-01

Polyamine metabolism in Acanthamoeba culbertsoni.

P Kishore, R M Wittich, R D Walter, O P Shukla

Index: Microbios 73(294) , 7-21, (1993)

Full Text: HTML

Abstract

1,3-Diaminopropane has been identified as the major polyamine of Acanthamoeba culbertsoni. N-acetylputrescine and spermidine were present in appreciable amounts and putrescine as well as N-acetylspermidine were also detected, but spermine was absent. Changes in polyamine levels were observed during the growth of amoebae. Ornithine decarboxylase activity was detected in cell-free extracts but there was very low activity of arginine and lysine decarboxylases. A potent polyamine oxidase was demonstrated which preferentially acted on N8-acetyl-spermidine as the substrate while N1-acetylspermidine was a poor substrate; free polyamines did not serve as a good substrate for this enzyme. Active uptake of polyamines by the amoebae was also demonstrated.

Related Compounds

  • N-Acetylputrescin...

Related Articles:

Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure.

2016-02-01

[J. Cell. Mol. Med. 20 , 302-12, (2016)]

Acetylated diamines inhibit endotoxin-induced lymphocyte activation.

1984-04-01

[J. Immunol. 132(4) , 1888-91, (1984)]

An improved gas chromatographic method for the determination of urinary acetylpolyamines.

1984-05-01

[Chem. Pharm. Bull. 32(5) , 1878-84, (1984)]

Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status.

2009-01-18

[Cancer Lett. 273(2) , 300-4, (2009)]

Effects of diacetyl diamines on in vitro activation and proliferation of human B lymphocytes.

1985-12-01

[J. Immunol. 135(6) , 3772-6, (1985)]

More Articles...