4-Benzyl-1 H-imidazoles with Oxazoline Termini as Histamine H3 Receptor Agonists

…, S Celanire, E Snip, MR Gillard, E Gelens…

Index: Wijtmans, Maikel; Celanire, Sylvain; Snip, Erwin; Gillard, Michel R.; Gelens, Edith; Collart, Philippe P.; Venhuis, Bastiaan J.; Christophe, Bernard; Hulscher, Saskia; Van Der Goot, Henk; Lebon, Florence; Timmerman, Henk; Bakker, Remko A.; Lallemand, Benedicte I. L. F.; Leurs, Rob; Talaga, Patrice E.; De Esch, Iwan J. P. Journal of Medicinal Chemistry, 2008 , vol. 51, # 10 p. 2944 - 2953

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Citation Number: 16

Abstract

Research on the therapeutic applications of the histamine H3 receptor (H3R) has traditionally focused on antagonists/inverse agonists. In contrast, H3R agonists have received less attention despite their potential use in several disease areas. The lower availability of H3R agonists not only hampers their full therapeutic exploration, it also prevents an unequivocal understanding of the structural requirements for H3R activation. ...