Synthesis

A new β-keto amide synthesis

Y Chen, SMN Sieburth

Index: Chen, Yanping; Sieburth, Scott McN. Synthesis, 2002 , # 15 p. 2191 - 2194

Full Text: HTML

Citation Number: 7

Abstract

Abstract In a modification of the Wierenga-Skulnick β-ketoester synthesis, the dianions of malonic acid mono-amides were condensed with acid chlorides. Acidic workup led to decarboxylation and isolation of the corresponding β-keto amides in good-to-excellent yields. A similar procedure with cyanoacetic acid gave β-keto nitriles.