FEBS Letters 2012-04-05

Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism.

T Andrew Clayton

Index: FEBS Lett. 586(7) , 956-61, (2012)

Full Text: HTML

Abstract

A novel explanation is proposed for the metabolic differences underlying two distinct rat urinary compositional phenotypes i.e. that these may arise from differences in the gut microbially-mediated metabolism of phenylalanine. As part of this hypothesis, it is further suggested that elements of the mammalian gut microbiota may convert phenylalanine to cinnamic acid, either by means of an ammonia lyase-type reaction or by means of a three step route via phenylpyruvate and phenyllactate. The wider significance of such conversions is discussed with similar metabolism of tryptophan and subsequent glycine conjugation potentially explaining the origin of trans-indolylacryloylglycine, a postulated marker for autism.Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Related Compounds

  • Sodium (benzoylami...
  • Hippuric acid

Related Articles:

Effects of dietary benzoic acid and sodium-benzoate on performance, nitrogen and mineral balance and hippuric acid excretion of piglets.

2012-06-01

[Arch. Anim. Nutr. 66(3) , 227-36, (2012)]

Alterations of urinary metabolite profile in model diabetic nephropathy.

2015-01-09

[Biochem. Biophys. Res. Commun. 456(2) , 610-4, (2015)]

Metabolomic profilings of urine and serum from high fat-fed rats via 1H NMR spectroscopy and pattern recognition.

2013-02-01

[Appl. Biochem. Biotechnol. 169(4) , 1250-61, (2013)]

Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency.

2015-01-01

[Sci. Rep. 5 , 11864, (2015)]

Metabolic influence of acute cyadox exposure on Kunming mice.

2013-01-04

[J. Proteome Res. 12(1) , 537-45, (2013)]

More Articles...