Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags

ZJ Ni, D Maclean, CP Holmes, MM Murphy…

Index: Ni, Zhi-Jie; Maclean, Derek; Holmes, Christopher P.; Murphy, Martin M.; Ruhland, Beatrice; Jacobs, Jeffrey W.; Gordon, Eric M.; Gallop, Mark A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1601 - 1608

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Citation Number: 132

Abstract

Encoded combinatorial organic synthesis has recently emerged as a powerful tool for the discovery of biologically active compounds from complex chemical libraries. This report describes a new encoding methodology that uses chemically robust secondary amines as tags. These amines are incorporated into an N-[(dialkylcarbamoyl) methyl] glycine-coding oligomer through simple chemistry that is compatible with a wide range of polymer- ...