Synthesis

Synthesis of novel halogenated 4 (1H)-quinolones by thermolysis of arylaminomethylene-1, 3-dioxane-4, 6-diones

S Rotzoll, H Reinke, C Fischer, P Langer

Index: Rotzoll, Sven; Reinke, Helmut; Fischer, Christine; Langer, Peter Synthesis, 2009 , # 1 p. 69 - 78

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Citation Number: 7

Abstract

Classic syntheses of 4(1H)-quinolones rely on the addition of (ethoxymethylene)malonates with anilines and subsequent cyclization [8] and on the addition of maleates to o-aminobenzoates and subsequent cyclization. [9] However, these methods are not suitable for the synthesis of 2,3-unsubstituted 4(1H)-quinolones as the ester groups present at these positions have to be removed in several steps. Heindel et al. reported [¹0] and elegant approach to 4(1H)- ...