Synthesis of analogs of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents

TP Johnston, GS McCaleb, SD Clayton…

Index: Johnston; McCaleb; Clayton; Frye; Krauth; Montgomery Journal of Medicinal Chemistry, 1977 , vol. 20, # 2 p. 279 - 290

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Citation Number: 29

Abstract

The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis-trans pairs. The methyl group was replaced by a variety of substituents (C02H, CH2C02H, C02Me, CH20Ac, CH2C1, OMe); the trans-3-methylcyclohexyl, cis-2- ...