Journal of the American Chemical Society

Synthesis of 7-Chloro-4-hydroxyquinoline Derivatives Employing Oxalacetic Ester1

GF Lisk, GW Stacy

Index: Lisk; Stacy Journal of the American Chemical Society, 1946 , vol. 68, p. 2686

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Citation Number: 5

Abstract

Andersag, Breitner and Jung3 prepared a number of 2-carbethoxy-4-hydroxyquinoline derivatives by thermal cyclization of P-carbethoxy-PI-anilinoacrylates, which themselves were obtained by the reaction of aromatic amines with oxalacetic ester. After removal of the carbethoxy group by hydrolysis and decarboxylation the 4-hydroxyquinolines were converted to 4-chloroquinolines which then could be condensed with basic side-c hains ...