Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity

…, Y Maeda, A Amagai, Y Kubohara, Y Oshima

Index: Kikuchi, Haruhisa; Sasaki, Kazunori; Sekiya, Jun'ichi; Maeda, Yasuo; Amagai, Aiko; Kubohara, Yuzuru; Oshima, Yoshiteru Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 12 p. 3203 - 3214

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Citation Number: 50

Abstract

Cellular slime molds are fascinating to the field of developmental biology, and have long been used as excellent model organisms for the study of various aspects of multicellular development. We have recently isolated α-pyronoids, named dictyopyrones A–D (1–4), from various species of Dictyostelium cellular slime molds, and it was shown that compound 3 may regulate Dictyostelium development. In this study, we synthesized dictyopyrones A–D ...

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