Biopolymers 2016-01-01

Postsynthetic modification of peptoids via the Suzuki-Miyaura cross-coupling reaction.

Ho Yeon Nam, Jiwon Seo

Index: Biopolymers 106 , 82-8, (2016)

Full Text: HTML

Abstract

We developed a new method for modifying the side chains of peptoids on a solid phase resin, employing the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. Optimized conditions using Pd(PPh3 )4 and K2 CO3 in the presence of Buchwald's SPhos ligand provided a high conversion in the coupling reaction. The usefulness of this method was demonstrated by synthesis of a two pyrene-conjugated peptoid helix, which exhibited an interesting excimer formation.© 2015 Wiley Periodicals, Inc.

Related Compounds

  • 4-Bromobenzylamine

Related Articles:

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.

2014-06-10

[Proc. Natl. Acad. Sci. U. S. A. 111(23) , 8428-33, (2014)]

Common metal of copper(0) as an efficient catalyst for preparation of nitriles and imines by controlling additives.

2014-05-30

[Chem. Commun. (Camb.) 50(42) , 5637-40, (2014)]

Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.

2007-06-01

[Bioorg. Med. Chem. 15(11) , 3896-911, (2007)]

Efficient synthesis of 2,6,9-triazabicyclo [3.3.1] nonanes through amine-mediated formal [4+4] reaction of unsaturated imines. Tanaka K, et al.

[Tetrahedron Lett. 53(44) , 5899-5902, (2012)]

Nitrogenous bisabolene sesquiterpenes from marine invertebrates. Gulavita NK, et al.

[J. Org. Chem. 51(26) , 5136-5139, (1986)]

More Articles...