Archiv der Pharmazie (Weinheim) 2005-12-01

New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.

Sun-Hee Lee, Sun-Kyoung Park, Jeong-Mi Kim, Myung-Hwa Kim, Kwang-Hee Kim, Kwang-Woo Chun, Kyung-Hea Cho, Ji-Youn Youn, Sung Keon Namgoong

Index: Arch. Pharm. (Weinheim) 338(12) , 582-9, (2005)

Full Text: HTML

Abstract

New thiocolchicine derivatives (1-8) were designed as less toxic anticancer agents possessing the power full anticancer activity of colchicine. The synthesis and biological evaluation of these compounds were described. As a preliminary result of biological in vitro investigation, compounds 1, 6, and 7 showed lower toxicities than that of colchicine in combination with potent anticancer activities.

Related Compounds

  • Thiocolchicine

Related Articles:

Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines.

1998-01-01

[Anticancer Drug Des. 13 , 19-33, (1998)]

Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.

1997-12-01

[Bioorg. Med. Chem. 5(12) , 2277-82, (1997)]

Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors.

2005-01-01

[Biochem. Pharmacol. 69(1) , 113-21, (2005)]

Derivatives of thiocolchicine and its applications to CEM cells treatment using 19F magnetic resonance ex vivo.

2010-02-01

[Bioorg. Chem. 38(1) , 1-6, (2010)]

Association of thiocolchicine with tubulin.

1989-06-15

[Biochem. Biophys. Res. Commun. 161(2) , 544-50, (1989)]

More Articles...