European Journal of Medicinal Chemistry 2012-09-01

Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.

Ola H Rizk, Omaima G Shaaban, Ibrahim M El-Ashmawy

Index: Eur. J. Med. Chem. 55 , 85-93, (2012)

Full Text: HTML

Abstract

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Related Compounds

  • 2-Acetoxy-2-methyl...

Related Articles:

Involvement of the essential metal transporter Zip14 in hepatic Cd accumulation during inflammation.

2013-03-27

[Toxicol. Lett. 218(1) , 91-6, (2013)]

Turpentine sensitization in a nonsteroidal anti-inflammatory solution user.

2012-01-01

[Dermatitis 23(4) , 182-3, (2012)]

Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.

2011-07-01

[Lab. Anim. 45(3) , 215-8, (2011)]

Phenotypic characterization of mononuclear inflammatory cells following equine hydroxyapatite/collagen block grafting in rats.

2012-12-01

[Biomed. Mater. 7(6) , 065005, (2012)]

Longitudinal observation of [11C]4DST uptake in turpentine-induced inflammatory tissue.

2013-02-01

[Nucl. Med. Biol. 40(2) , 240-4, (2013)]

More Articles...