Biochimica et Biophysica Acta 2013-09-01

Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol.

Tatyana M Konyakhina, Jing Wu, James D Mastroianni, Frederick A Heberle, Gerald W Feigenson

Index: Biochim. Biophys. Acta 1828(9) , 2204-14, (2013)

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Abstract

We report the first 4-component phase diagram for the lipid bilayer mixture, DSPC/DOPC/POPC/chol (distearoylphosphatidylcholine/dioleoylphosphatidylcholine/1-palmitoyl, 2-oleoylphosphatidylcholine/cholesterol). This phase diagram, which has macroscopic Ld+Lo phase domains, clearly shows that all phase boundaries determined for the 3-component mixture containing DOPC transition smoothly into the boundaries for the 3-component mixture containing POPC, which has nanoscopic phase domains of Ld+Lo. Our studies start from two published ternary phase diagrams, and show how these can be combined into a quaternary phase diagram by study of a few hundred samples of intermediate compositions. Copyright © 2013 Elsevier B.V. All rights reserved.

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