Basic & Clinical Pharmacology & Toxicology 2012-11-01

A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.

Jiri Kassa, Jan Misik, Jana Zdarova Karasova

Index: Basic Clin Pharmacol Toxicol. 111(5) , 333-8, (2012)

Full Text: HTML

Abstract

The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with sarin were studied. The sarin-induced neurotoxicity was monitored using a functional observatory battery at 2 hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin-induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI-6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI-6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings.© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.

Related Compounds

  • Asoxime dichloride
  • Obidoxime dichlori...

Related Articles:

Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.

2015-02-03

[Toxicol. Lett. 232(3) , 557-65, (2015)]

The effect of oxime reactivators on muscarinic receptors: functional and binding examinations.

2011-05-01

[Environ. Toxicol. Pharmacol. 31(3) , 364-70, (2011)]

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.

2013-03-25

[Chem. Biol. Interact. 203(1) , 81-4, (2013)]

Investigation of oxidative stress in blood, brain, kidney, and liver after oxime antidote HI-6 application in a mouse experimental model.

2011-07-01

[Drug Chem. Toxicol. 34(3) , 255-60, (2011)]

Photostability of antidotal oxime HI-6, impact on drug development.

2012-01-01

[Drug Test. Anal. 4(3-4) , 208-14, (2012)]

More Articles...