International Journal of Surgery 2009-04-01

The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy.

Tayfun Yucel, Dogan Gonullu, Ahmet Orhan Gurer, Ruhan Duzman, Ferda Nihat Koksoy, Necati Yilmaz, Mustafa Sit

Index: Int. J. Surg. 7(2) , 163-7, (2009)

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Abstract

The effects on gastric emptying of feeding with a normal diet (ND), an early high-calorie and hyperosmolar diet (HCHOD) or normal diet plus intraperitoneal loxiglumide (LOX) were investigated in rats with antecolic (ACGJ) or retrocolic (RCGJ) gastrojejunostomy.Sixty rats were separated into six groups of ten animals each (ACGJ+ND, RCGJ+ND, ACGJ+HCHOD, RCGJ+HCHOD, ACGJ+ND+LOX, and RCGJ+ND+LOX). On the seventh day, scintigraphic measurements of solid gastric emptying were made at 1, 30 and 60 min.According to the 60-min results, the RCGJ+ND group exhibited delayed emptying compared to the ACGJ+ND group (p=0.023). Gastric emptying of ACGJ+HCHOD rats was delayed compared with the other ACGJ groups (compared to ACGJ+ND: p=0.000, and ACGJ+ND+LOX: p=0.015). Gastric emptying was more effective in the RCGJ+ND+LOX group than the other RCGJ groups (compared to RCGJ+ND: p=0.003, and RCGJ+HCHOD: p=0.001).Antecolic gastrojejunostomy provided better gastric emptying. An early high-calorie and hyperosmolar enteral diet delayed gastric emptying in both types of anastomosis.

Related Compounds

  • Loxiglumide

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