Organic Letters 2012-12-21

Three-component reaction of propargyl amines, sulfonyl azides, and alkynes: one-pot synthesis of tetrasubstituted imidazoles.

Zheng Jiang, Ping Lu, Yanguang Wang

Index: Org. Lett. 14(24) , 6266-9, (2012)

Full Text: HTML

Abstract

An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.

Related Compounds

  • pargyline hydrochl...
  • Prop-2-yn-1-aminiu...

Related Articles:

Chemical genetics reveals a complex functional ground state of neural stem cells.

2007-05-01

[Nat. Chem. Biol. 3(5) , 268-273, (2007)]

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

2009-10-01

[Nat. Chem. Biol. 5 , 765-71, (2009)]

Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties.

2014-11-11

[Life Sci. 117(2) , 56-66, (2015)]

Origins of stereoselectivities in chiral phosphoric acid catalyzed allylborations and propargylations of aldehydes.

2013-02-01

[J. Org. Chem. 78(3) , 1208-15, (2013)]

Divergent reaction pathways of homologous and isosteric propargyl amides in sequential Ru/Pd-catalyzed annulations for the synthesis of heterocycles.

2013-04-19

[J. Org. Chem. 78(8) , 3832-46, (2013)]

More Articles...