Scientific reports 2011-01-01

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.

Hongzhe Li, Peter S Steyger

Index: Sci. Rep. 1 , 159, (2011)

Full Text: HTML

Abstract

Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion.

Related Compounds

  • Sulforhodamine 101...

Related Articles:

Distribution of acetylcholine and catecholamines in fish gills and their potential roles in the hypoxic ventilatory response.

2013-03-01

[Acta Histochem. 115(2) , 158-69, (2013)]

Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function.

2013-01-01

[Brain. Behav. Immun. 27(1) , 80-90, (2013)]

In vivo evaluation of venular glycocalyx during hemorrhagic shock in rats using intravital microscopy.

2013-01-01

[Microvasc. Res. 85 , 128-33, (2013)]

Optical modulation and selective recovery of Cy5 fluorescence.

2012-03-01

[ChemPhysChem 13(4) , 1023-9, (2012)]

Aggregation effects of gold nanoparticles for single-base mismatch detection in influenza A (H1N1) DNA sequences using fluorescence and Raman measurements.

2012-05-01

[Colloids Surf. B Biointerfaces 93 , 148-53, (2012)]

More Articles...