Pest Management Science 2004-04-01

Synthesis and structure-activity study of fungicidal anilinopyrimidines leading to mepanipyrim (KIF-3535) as an anti-Botrytis agent.

Toshihiro Nagata, Katsumi Masuda, Shinichiro Maeno, Ichiro Miura

Index: Pest Manag. Sci. 60(4) , 399-407, (2004)

Full Text: HTML

Abstract

A series of 2-anilinopyrimidines was prepared and their fungicidal activities against Botrytis cinerea Pers were examined. The activity fell sharply with any substitution on the anilinobenzene ring. Substituents at the 5-position of the pyrimidine ring greatly reduced the activity. Substituents such as chloro, methoxy, methylamino, methyl or 1-propynyl were well tolerated at the 4- and 6-positions of the pyrimidine ring. Among these substituents, the combination of methyl and 1-propynyl groups was the most favourable. 2-Anilino-4-methyl-6-(1-propynyl)pyrimidine (KIF-3535), which showed excellent activity and no significant phytotoxicity, was finally selected for development and has been given the common name mepanipyrim.

Related Compounds

  • 4-METHYL-N-PH...

Related Articles:

Gas chromatographic determination of azoxystrobin, fluazinam, kresoxim-methyl, mepanipyrim, and tetraconazole in grapes, must, and wine.

1998-01-01

[J. AOAC Int. 81(6) , 1185-9, (1998)]

Evaluation of anilinopyrimidine and other fungicides for control of grey mould (Botrytis cinerea) in container-grown Calluna vulgaris.

2008-07-01

[Pest Manag. Sci. 64(7) , 748-54, (2008)]

[Determination of fungicide anilinopyrimidine residues in food by series solid phase extraction-high performance liquid chromatography-tandem mass spectrometry].

2012-09-01

[Se Pu 30(9) , 896-902, (2012)]

Degradation of anilinopyrimidine fungicides photoinduced by iron(III)-polycarboxylate complexes.

2006-09-01

[Pest Manag. Sci. 62(9) , 872-9, (2006)]

Effects of mepanipyrim on lipid metabolism in rats.

1998-08-01

[J. Toxicol. Sci. 23(3) , 235-41, (1998)]

More Articles...