An improved modification of Ritter reaction

…, ET Vilar, AG Fraile, M Hanack, LR Subramanian

Index: Martinez, A. Garcia; Alvarez, A. Martinez; Vilar, E. Teso; Fraile, A. Garcia; Hanack, M.; Subramanian, L. R. Tetrahedron Letters, 1989 , vol. 30, # 5 p. 581 - 582

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Citation Number: 75

Abstract

The reaction of alcohols with nitriles in concentrated sulfuric acid (Ritter reaction) has been proved to be a good method for the preparation of primary and secundary amines via the hydrolysis or reduction of the initially formed amides'. The Ritter reaction has the disadvantage that it functions well (50-90X yield) only in the case of tertiary alcohols 1 CR', R2, R3,+ H). Thus the yields of the amides are low in the case of secondary alcohols, ...

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