Chemical Biology & Drug Design 2009-06-01

Novel pleuromutilin derivatives with excellent antibacterial activity against Staphylococcus aureus.

Peng Xu, Yuan-Yuan Zhang, Yong-Xue Sun, Jian-Hua Liu, Bing Yang, Yu-Zhong Wang, Yu-Liang Wang

Index: Chem. Biol. Drug Des. 73(6) , 655-60, (2009)

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Abstract

Ten novel pleuromutilin derivatives with thioether moiety and heterocyclic carboxamide or chloroformate group in the side chain were synthesized and confirmed by (1)H NMR, IR and HRMS. The results of the antibacterial activity showed that the title compounds had excellent antibacterial activity against Staphylococcus aureus, among which the MIC of 5f reached 0.03125 microg/mL.

Related Compounds

  • Pleuromutilin

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