Bioorganic & Medicinal Chemistry 2008-01-01

Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.

John W Huffman, Alicia L S Thompson, Jenny L Wiley, Billy R Martin

Index: Bioorg. Med. Chem. 16 , 322-35, (2008)

Full Text: HTML

Abstract

A series of 1-deoxy analogs of CP-47,497 (8 and 13, n=0-7) and 1-deoxy analogs of CP-55,940 (9, n=0-7) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although the majority of these compounds exhibit selectivity for the CB(2) receptor, none have greater than modest affinity for either receptor. The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed.

Related Compounds

  • 1-Bromo-4-tert-but...
  • (-)-δ9-trans-Tetra...

Related Articles:

Effect of solvent on the lithium-bromine exchange of aryl bromides: reactions of n-butyllithium and tert-butyllithium with 1-bromo-4-tert-butylbenzene at 0 degrees C.

2006-03-31

[J. Org. Chem. 71(7) , 2825-8, (2006)]

Novel non-symmetric nickel-diimine complexes for the homopolymerization of ethene: Control of branching by catalyst design. Schmid M, et al.

[Z. Naturforsch. B 57(10) , 1141-46, (2002)]

More Articles...