A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity

H Huang, Q Chen, X Ku, L Meng, L Lin…

Index: Journal of Medicinal Chemistry, , vol. 53, # 8 p. 3048 - 3064

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Citation Number: 113

Abstract

... Journal of Medicinal Chemistry. ... However, the therapeutic potential of 3-AP was limited by its poor water solubility and toxicity profile.(17) Therefore, there is increasing interest in structural modification of TSC derivatives with the aim of improving the pharmaceutical profile of ...

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