Journal of Organometallic Chemistry

An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP 2 Mg· 2LiCl in the presence of ZnCl 2

ZB Dong, WH Zhu, ZG Zhang, MZ Li

Index: Dong, Zhi-Bing; Zhu, Wei-Hua; Zhang, Zhi-Guang; Li, Min-Zhi Journal of Organometallic Chemistry, 2010 , vol. 695, # 5 p. 775 - 780

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Citation Number: 1

Abstract

A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP2Mg· 2LiCl (TMP= 2, 2, 6, 6-tetramethylpiperamidyl) in the presence of ZnCl2. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. A detailed study concerned on the point how we found the protocol and how we optimized it was depicted.