Planta Medica 2010-03-01

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.

Lucia Acebey, Valérie Jullian, Denis Sereno, Séverine Chevalley, Yannick Estevez, Claude Moulis, Stephan Beck, Alex Valentin, Alberto Gimenez, Michel Sauvain

Index: Planta Med. 76 , 365-8, (2010)

Full Text: HTML

Abstract

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM. The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.Copyright Georg Thieme Verlag KG Stuttgart New York.

Related Compounds

  • Chloroquine diphos...
  • Pentamidine isethi...

Related Articles:

Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.

2014-07-01

[Autophagy 10(7) , 1241-55, (2014)]

Regulators of autophagosome formation in Drosophila muscles.

2015-02-01

[PLoS Genet. 11(2) , e1005006, (2015)]

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.

2015-02-01

[Mol. Pharmacol. 87(2) , 323-37, (2015)]

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.

2015-09-01

[J. Pineal Res. 59 , 178-89, (2015)]

Quantitation of secreted proteins using mCherry fusion constructs and a fluorescent microplate reader.

2015-03-15

[Anal. Biochem. 473 , 34-40, (2015)]

More Articles...