Synthesis and anti-viral activity of azolo-adamantanes against influenza A virus

VV Zarubaev, EL Golod, PM Anfimov, AA Shtro…

Index: Zarubaev, Vladimir V.; Golod, Efim L.; Anfimov, Pavel M.; Shtro, Anna A.; Saraev, Victor V.; Gavrilov, Alexey S.; Logvinov, Alexander V.; Kiselev, Oleg I. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 839 - 848

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Citation Number: 50

Abstract

Chemotherapy and chemoprophylaxis of influenza is one of the most important directions of health protection activity. Due to the high rate of drug-resistant strains of influenza virus, there is a need for the search and further development of new potent antivirals against influenza with a broad spectrum of activity. In the present study, a set of di-, tri-and tetrazole derivatives of adamantane was efficiently prepared and their anti-influenza activities ...