Nonenzymatic Conversion of Penicillins to 6-Aminopenicillanic Acid

DA Johnson, CA Panetta, RR Smith

Index: Johnson; Panetta; Smith The Journal of organic chemistry, 1966 , vol. 31, # 8 p. 2560 - 2564

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Citation Number: 9

Abstract

The nonenzymatic conversion of several o-nitrophenyl-substituted penicillins (3) to 6- aminopenicillanic acid (8) is reported. Spontaneous cleavage of the side chain occurs at room temperature after reduction to the substituted amine (4) with hydrogen over palladium

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