Practical Synthesis of β??Carbonyl Phenyltetrazolesulfones and Investigations of Their Reactivities in Organocatalysis

…, M Nielsen, J Overgaard, CB Jacobsen…

Index: Zweifel, Theo; Nielsen, Martin; Overgaard, Jacob; Jacobsen, Christian Borch; Jorgensen, Karl Anker European Journal of Organic Chemistry, 2011 , # 1 p. 47 - 52

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Citation Number: 13

Abstract

Abstract A practical synthesis of β-carbonyl phenyltetrazolesulfones, useful for a series of enantioselective reactions, is shown. Aryl, alkyl and ester carbonyl compounds all proved to be efficiently synthesised, leading to products in up to> 99% yield over two steps. During this procedure, no special attention to conditions or laborious purification by chromatography is needed. Furthermore, X-ray crystallography, kinetic studies, as well as NMR and IR ...