Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1999-10-29

Studies on the genotoxic effects of aminophenazines using two cellular models and three different methods.

A Cebulska-Wasilewska, D Nowak, W Niedzwiedz, E D Wagner, M J Plewa

Index: Mutat. Res. 446(1) , 57-65, (1999)

Full Text: HTML

Abstract

This paper presents studies on the genotoxicity of two aminophenazines: 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP). The genotoxic activities of these compounds were evaluated with human lymphocytes using the alkaline single cell gel electrophoresis (SCGE) assay and two cytogenetic assays (chromosome aberrations (CA) and sister chromatid exchange (SCE) analysis). Results show that these chemicals elicited an increase in DNA and chromosomal damage under the studied ranges of concentration. Concentration-response curves were similar and there was a positive correlation between the damage observed at the DNA and chromosomal levels. DAP was more genotoxic than AHP and this agreed with the genotoxic potencies reported in bacterial systems.

Related Compounds

  • 2,3-Diaminophenazi...

Related Articles:

Spectrophotometric quantification of horseradish peroxidase with o-phenylenediamine.

2010-12-15

[Anal. Biochem. 407(2) , 293-5, (2010)]

Spectrophotometric quantification of lactose in solution with a peroxidase-based enzymatic cascade reaction system.

2011-10-01

[Anal. Bioanal. Chem 401 , 2307-2310, (2011)]

Photoinduced DNA cleavage and cellular damage in human dermal fibroblasts by 2,3-diaminophenazine.

2005-01-01

[Photochem. Photobiol. 81(1) , 89-95, (2005)]

Experimental (FT-IR, FT-Raman and UV-Vis) spectra and theoretical DFT investigations of 2,3-diaminophenazine.

2012-10-01

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 401-12, (2012)]

[The study on reaction kinetics based on a new system of the horseradish peroxidase catalyting the oxidation of o-phenylenediamine by H2O2].

2002-06-01

[Guang Pu Xue Yu Guang Pu Fen Xi 22(3) , 436-40, (2002)]

More Articles...