Journal of Biomedicine and Biotechnology 2012-01-01

Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin.

Takuji Tanaka, Takahiro Tanaka, Mayu Tanaka, Toshiya Kuno

Index: J. Biomed. Biotechnol. 2012 , 516981, (2012)

Full Text: HTML

Abstract

β-Cryptoxanthin, a carotenoid, and hesperidin, a flavonoid, possess inhibitory effects on carcinogenesis in several tissues. We recently have prepared a pulp (CHRP) and citrus juices (MJ2 and MJ5) from a satsuma mandarin (Citrus unshiu Mar.) juice (MJ). They contain high amounts of β-cryptoxanthin and hesperidin. We have demonstrated that CHRP and/or MJs inhibit chemically induced rat colon, rat tongue, and mouse lung tumorigenesis. Gavage with CHRP resulted in an increase of activities of detoxifying enzymes in the liver, colon, and tongue rats'. CHRP and MJs were also able to suppress the expression of proinflammatory cytokines and inflammatory enzymes in the target tissues. This paper describes the findings of our in vivo preclinical experiments to develop a strategy for cancer chemoprevention of colon, tongue, and lung neoplasms by use of CHRP and MJs.

Related Compounds

  • Cryptoxanthin
  • Hesperidin

Related Articles:

Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.

2013-11-22

[J. Biol. Chem. 288(47) , 34081-96, (2013)]

The effects of daily consumption of β-cryptoxanthin-rich tangerines and β-carotene-rich sweet potatoes on vitamin A and carotenoid concentrations in plasma and breast milk of Bangladeshi women with low vitamin A status in a randomized controlled trial.

2013-11-01

[Am. J. Clin. Nutr. 98(5) , 1200-8, (2013)]

Degradation of carotenoids in apricot (Prunus armeniaca L.) during drying process.

2013-09-01

[Plant Foods Hum. Nutr. 68(3) , 241-6, (2013)]

Specific carotenoid intake is inversely associated with the risk of breast cancer among Chinese women.

2014-05-01

[Br. J. Nutr. 111(9) , 1686-95, (2014)]

Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children.

2013-12-01

[Br. J. Nutr. 110(12) , 2309-17, (2013)]

More Articles...