Protein & Peptide Letters 2002-10-01

The use of DODT as a non-malodorous scavenger in Fmoc-based peptide synthesis.

A Teixeira, W E Benckhuijsen, P E de Koning, A R P M Valentijn, J W Drijfhout

Index: Protein Pept. Lett. 9(5) , 379-85, (2002)

Full Text: HTML

Abstract

We have synthesized a random group of peptides and performed cleavages using various cleavage cocktails including 3,6-dioxa-1,8-octanedithiol (DODT). Purity of the peptides was compared to that obtained with standard protocols for cleavage using RP-HPLC and Maldi-Tof mass spectrometry. We show that stinking thiols can be replaced by the almost odourless (DODT) without negatively affecting the purity of the end product.

Related Compounds

  • 3,6-DIOXA-1,8-O...

Related Articles:

The influence of linker length on the properties of cathepsin S cleavable177Lu-labeled HPMA copolymers for pancreatic cancer imaging

2014-02-10

[Biomaterials 35(22) , 5760-70, (2014)]

Dual-targeted polyplexes based on sequence-defined peptide-PEG-oligoamino amides.

2015-02-01

[J. Pharm. Sci. 104(2) , 464-75, (2015)]

Development and in vitro assessment of enzymatically-responsive poly(ethylene glycol) hydrogels for the delivery of therapeutic peptides.

2014-12-01

[Biomaterials 35(36) , 9719-30, (2014)]

Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition.

2014-05-01

[PLoS Negl. Trop. Dis. 8(5) , e2892, (2014)]

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

2009-07-01

[Nucleic Acids Res. 12th ed., 37 , 4116-4126, (2009)]

More Articles...