Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging

…, AL Brownell, DR Elmaleh, BK Madras

Index: Meltzer, P. C.; Liang, A. Y.; Brownell, A.-L.; Elmaleh, D. R.; Madras, B. K. Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 855 - 862

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Citation Number: 141

Abstract

In recent years cocaine has become one of the most prevalent and problematic drugs of abuse and considerable effort has been expended in the study of ita mechanisms of action. It is now widely accepted that (-)-cocaine, a stimulant and powerful reinforcer, binds to specific recognition sites associated with monoamine transporters112 in the mammalian brain. Ita primary mechanism of action has been ascribed to its ability to inhibit the ...

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