Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists

RA Glennon, JJ Salley Jr, OS Steinsland…

Index: Glennon; Salley Jr.; Steinsland; Nelson Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 678 - 683

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Citation Number: 13

Abstract

Several alkylpiperazines, monocyclic subfragments of known tricyclic neuroleptic agents, were evaluated as dopamine antagonists in the isolated rabbit ear artery preparation. Compounds prepared and evaluated are of the general structure Ar-X-(CH,),-Y, where X= C, 0, and N, n= 1-3, and Y, for the most part, was 4-methylpiperwine. Those compounds where X= NH, n= 3, and X=(2)-CH= CH, n= 2, with an electron-withdrawing group meta to the ...

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