Synthesis and antitumor activity of several new analogues of penclomedine and its metabolites

A Tiwari, JM Riordan, WR Waud…

Index: Journal of Medicinal Chemistry, , vol. 45, # 5 p. 1079 - 1085

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Citation Number: 4

Abstract

... Journal of Medicinal Chemistry. ... Introduction. PEN 1 (3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl) pyridine) is a chemical alkylating agent as revealed by its facile reaction with 4-(p-nitrobenzyl) pyridine in the Epstein test 2 (unpublished results). Plowman et al. ...