Journal of Organic Chemistry 2012-07-20

Aminoindolines versus quinolines: mechanistic insights into the reaction between 2-aminobenzaldehydes and terminal alkynes in the presence of metals and secondary amines.

Nitin T Patil, A Nijamudheen, Ayan Datta

Index: J. Org. Chem. 77(14) , 6179-85, (2012)

Full Text: HTML

Abstract

DFT computational studies in the cyclization of aminoalkyne (see structure), which is generated in situ by 2-aminobenzaldehydes and terminal alkynes in the presence of metals and secondary amines, has been investigated. The study revealed that the mode of cyclization (exo vs endo) depends on the protecting group on nitrogen, the oxidation state of copper, and substitution on alkyne.

Related Compounds

  • Formylaniline

Related Articles:

Chondrogenesis of human bone marrow mesenchymal stromal cells in highly porous alginate-foams supplemented with chondroitin sulfate.

2015-05-01

[Mater. Sci. Eng. C. Mater. Biol. Appl. 50 , 160-72, (2015)]

B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.

2014-01-01

[PLoS ONE 9(5) , e95998, (2014)]

The consequences of the isotope effect on proline dehydrogenation rates estimated by the tritium loss method.

1992-06-01

[Anal. Biochem. 203(2) , 191-200, (1992)]

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.

2016-03-01

[Amino Acids 48 , 859-72, (2016)]

Functional specialization in proline biosynthesis of melanoma.

2012-01-01

[PLoS ONE 7 , e45190, (2012)]

More Articles...