Tetrahedron

A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides

J Shao, X Huang, S Wang, B Liu, B Xu

Index: Shao, Jun; Huang, Xiaomei; Wang, Siyuan; Liu, Bingxin; Xu, Bin Tetrahedron, 2012 , vol. 68, # 2 p. 573 - 579

Full Text: HTML

Citation Number: 18

Abstract

An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N- monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate (TBAHS) was described. This reaction provides a very simple and convenient synthetic route to N-monosubstituted α-keto amides from easily available aryl-or heteroarylacetamides in good to high yields without using toxic reagents and harsh conditions.

Related Articles:

Preparation of some stable and transient 1, 3-oxazolium-4-olates

[Haddadin, Makhluf J.; Tannus, Hana T. Heterocycles, 1984 , vol. 22, # 4 p. 773 - 778]

A simple, efficient, regioselective and one-pot preparation of N-hydroxy-and N–O-protected hydroxyindoles via cycloaddition of nitrosoarenes with alkynes. Synthetic …

[Ieronimo, Gabriella; Mondelli, Alessandro; Tibiletti, Francesco; Maspero, Angelo; Palmisano, Giovanni; Galli, Simona; Tollari, Stefano; Masciocchi, Norberto; Nicholas, Kenneth M.; Tagliapietra, Silvia; Cravotto, Giancarlo; Penoni, Andrea Tetrahedron, 2013 , vol. 69, # 51 p. 10906 - 10920]

Amidophosphine-Phosphinites: Synthesis and Use in Rhodium-Based Asymmetric Hydrogenation of Activated Keto Compounds. Crystal Structure of Bis [(μ-chloro)((S …

[Tani, Kazuhide; Suwa, Kenichi; Tanigawa, Eiji; Ise, Tomokazu; Yamagata, Tsuneaki; et al. Journal of Organometallic Chemistry, 1989 , vol. 370, p. 203 - 222]

Reaction of 4??aryl??1, 2, 4??triazines with hydrazine

[Ibrahim, Y. A.; Eid, M. M.; Badawy, M. A.; Abdel-Hady, S. A. L. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 953 - 956]

Unprecedented 1, 3-dipolar cycloaddition of azomethine ylides to ester carbonyl

[Novikov, Mikhail S.; Voznyi, Igor V.; Khlebnikov, Alexander F.; Kopf, Juergen; Kostikov, Rafael R. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 14 p. 1628 - 1630]

More Articles...