A versatile procedure for the generation of nucleoside 5′-carboxylic acids using nucleoside oxidase

…, M Chandler, DG Livermore, NJ Turner, G Jenkins

Index: Mahmoudian, Mahmoud; Rudd, Brian A.M.; Cox, Brian; Drake, Chris S.; Hall, Richard M.; Stead, Paul; Dawson, Michael J.; Chandler, Malcolm; Livermore, David G.; Turner, Nicholas J.; Jenkins, Gareth Tetrahedron, 1998 , vol. 54, # 28 p. 8171 - 8182

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Citation Number: 30

Abstract

The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5′-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale.