Ru-catalyzed β-selective and enantioselective addition of amines to styrenes initiated by direct arene-exchange

…, H Yokoyama, K Endo, T Shibata

Index: Otsuka, Maiko; Yokoyama, Hiroya; Endo, Kohei; Shibata, Takanori Organic and Biomolecular Chemistry, 2012 , vol. 10, # 19 p. 3815 - 3818

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Citation Number: 9

Abstract

On the other hand, we have previously developed the catalytic S N Ar reaction of nonactivated arenes with amines using [Ru(benzene)Cl 2 ] 2 , AgOTf, and P(p-FC 6 H 4 ) 3 . 5 This reaction proceeded via η 6 -fluoroarene ruthenium complexes, which were generated in situ by direct arene-exchange of the benzene coordinated to ruthenium with fluoroarenes. We then hypothesized that the desired catalytic β-selective nucleophilic addition to styrenes could proceed using ...

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