Development of a scalable synthesis of GSK183390A, a PPAR α/γ agonist

LM Oh, H Wang, SC Shilcrat…

Index: Organic Process Research and Development, , vol. 11, # 6 p. 1032 - 1042

Full Text: HTML

Citation Number: 13

Abstract

... It was found that temperature control was again critical in this process. ... The organic layer containing pyrazole 5 was then concentrated and diluted with THF, and the hydrolysis to pyrazole acid ... This procedure was scaled up in the pilot plant to deliver a total of 28.1 kg of pyrazole ...

Related Articles:

Ruthenium-catalyzed carbonylation of allene: direct synthesis of methacrylates and methacrylamides

[Zhou, Da-Yang; Yoneda, Eiji; Onitsuka, Kiyotaka; Takahashi, Shigetoshi Chemical Communications, 2002 , # 23 p. 2868 - 2869]

H??transfer reaction during decomposition of N??(2??methylpropyl)??N??(1??diethylphosphono??2, 2??dimethylpropyl)??N??oxyl (SG1)??based alkoxyamines

[Journal of Polymer Science, Part A: Polymer Chemistry, , vol. 51, # 6 p. 1323 - 1336]

Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling†,‡

[Journal of Organic Chemistry, , vol. 75, # 10 p. 3401 - 3411]

Pentacarbonylmanganese enolate and dienolate complexes. Preparative and mechanistic considerations

[Canadian Journal of Chemistry, , vol. 68, # 3 p. 492 - 501]

Pentacarbonylmanganese enolate and dienolate complexes. Preparative and mechanistic considerations

[Canadian Journal of Chemistry, , vol. 68, # 3 p. 492 - 501]

More Articles...