Synthesis and pharmacological evaluation of 4, 4-disubstituted piperidines

JA Colapret, G Diamantidis, HK Spencer…

Index: Colapret; Diamantidis; Spencer; Spaulding; Rudo Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974

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Citation Number: 36

Abstract

A new class of piperidine derivatives is added to the increasing family of compounds related to fentanyl and carfentanil. Herein, we describe the synthesis and pharmacology of a number of l-(arylethyl)-4-(acylamino)-4-[(acyloxy)-methyllpiperidines such as 9, 15, and 23. As expected, many of these congeners of fentanyl are extremely potent narcotic agonists. The aim of the study was to identify short-acting analgesic agents (Le. less than 6 min in ...