Analogs of aminoglutethimide based on 1-phenyl-3-azabicyclo [3.1. 0] hexane-2, 4-dione: selective inhibition of aromatase activity

…, M Jarman, J Stanek, E Schweizer

Index: Rowlands; Bunnett; Foster; Jarman; Stanek; Schweizer Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 971 - 976

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Citation Number: 14

Abstract

In exploring the structural features responsible for the inhibitory activity of aminoglutethimide [3-(4-amino-phenyl)-3-ethylpiperidine-2, 6-dione](1) toward the cholesterol side chain cleavage (CSCC) enzyme from bovine adrenals and the human placental aromatase enzyme, analogues have been synthesized in which the piperidine-2, g-dione ring is replaced by substituted or unsubstituted azabicyclo [3. l. 0] hexane-2, 4-dione rings. The ...

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