Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.

Yuli Xie, Yidong Liu, Gangli Gong, Deborah H Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi-Xian Deng, Lars Branden, Dusica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D Hammock, Donald W Landry

Index: Bioorg. Med. Chem. Lett. 19(8) , 2354-9, (2009)

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Abstract

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.