FEBS Letters 1992-06-29

1H NMR study on the conformation of bacitracin A in aqueous solution.

N Kobayashi, T Takenouchi, S Endo, E Munekata

Index: FEBS Lett. 305(2) , 105-9, (1992)

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Abstract

The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1-6) is folded over the cyclic ring, resulting in metal coordination sites, a thiazoline ring, and Glu4 and His10 being proximate to each other.

Related Compounds

  • Bacitracin A1 (9C...

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