The Synthesis of 1, 3, 4-Benzotriazepin-5-one Derivatives from Isatoic Anhydrides

M Takahashi, S Onizawa, T Satoh

Index: Takahashi,M. et al. Bulletin of the Chemical Society of Japan, 1974 , vol. 47, p. 2724 - 2726

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Citation Number: 12

Abstract

The reaction of isatoic anhydrides (1) with 2-pyridylamidrazone afforded N-(2-aminophenyl)- 2-pyridylamidrazones (2), which were then cyclized with acid to 1, 3, 4-benzotriazepin-5-one derivatives (3). The treatment of isatoic anhydride with 2-pyridylcarbonohydrazide gave 1-(2- aminophenyl)-2-(2-pyridinecarbonyl)-hydrazine (5), which was then dehydrated with polyphosphoric acid to 3-(2-aminophenyl)-5-(2-pyridyl)-1, 3, 4-oxadiazole (6), but not to 3.