Synthesis and antiulcer activity of N-substituted N'-[3-[3-(piperidinomethyl) phenoxy] propyl] ureas: histamine H2-receptor antagonists with potent mucosal protective …

M Miyashita, T Matsumoto, H Matsukubo…

Index: Miyashita; Matsumoto; Matsukubo; Iinuma; Taga; Sekiguchi; Hamada; Okamura; Nishino Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2446 - 2451

Full Text: HTML

Citation Number: 7

Abstract

As an aim toward developing new antiulcer agents, new N-substituted N'-[3-[3- (piperidinomethyl) phenoxy] propyl] urwrs were synthesized and evaluated for histamine H2- receptor antagonistic, gastric antisecretory, and gastric mucosal protective activities. A QSAR study showed that the most favorable N-substituents were electron-donating stmightchain alkyl groups of short length such as ethyl group from the viewpoint of dual ...