Molecular and Biochemical Parasitology 1988-02-01

Correlation of the efficiency of fatty acid derivatives in suppressing Plasmodium falciparum growth in culture with their inhibitory effect on acyl-CoA synthetase activity.

B D Beaumelle, H J Vial

Index: Mol. Biochem. Parasitol. 28(1) , 39-42, (1988)

Full Text: HTML

Abstract

The intraerythrocytic malaria parasite depends on the surrounding medium for a supply of phospholipid precursors. Efficient inhibition (IC50 7-90 microM) of Plasmodium falciparum growth in vitro was achieved using modified fatty acids. The fatty acid analogues most effective in suppressing P. falciparum growth in culture were also the most active inhibitors of acyl-CoA synthetase from the monkey parasite P. knowlesi.

Related Compounds

  • 2-hydroxy Palmitic...

Related Articles:

Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.

2007-10-01

[J. Pept. Sci. 13 , 634-641, (2007)]

Determination of glucosylceramide contents in crop tissues and by-products from their processing.

2005-06-01

[Bioresour. Technol. 96 , 1089-1092, (2005)]

The effects of hydroxy fatty acids on the hyphal branching of germinated spores of AM fungi.

2011-01-01

[Fungal Biol. 115 , 351-358, (2011)]

Flip-flop of hydroxy fatty acids across the membrane as monitored by proton-sensitive microelectrodes.

2008-05-01

[Biochim. Biophys. Acta 1778 , 1292-1297, (2008)]

Transport of fatty acids across membranes by the diffusion mechanism.

1999-01-01

[Prostaglandins Leukot. Essent. Fatty Acids 60 , 291-297, (1999)]

More Articles...