Organic Letters 2002-07-25

Resolution of 1-(2-naphthyl)ethanol by a combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction.

Zhiyong Luo, Sauda M Swaleh, Fritz Theil, Dennis P Curran

Index: Org. Lett. 4(15) , 2585-7, (2002)

Full Text: HTML

Abstract

[reaction: see text] Kinetic resolution of a fluorous ester rac-1 with Candida antarctica B lipase provided a mixture of enantioenriched alcohol (R)-2 and fluorous ester (S)-1. The mixture was subjected to a fluorous triphasic reaction to give both enantiomers of 1-(2-naphthyl)ethanol 2 in high ee without chromatographic separation or fluorous-organic liquid-liquid extractive purification.

Related Compounds

  • naphthalen-1-ethan...

Related Articles:

The role of weak hydrogen bonds in chiral recognition.

2011-10-28

[Phys. Chem. Chem. Phys. 13(40) , 17916-29, (2011)]

Fluorescence detection of surface-bound intermediates produced from UV photoreactivity of alkylsiloxane SAMs.

2004-03-03

[J. Am. Chem. Soc. 126(8) , 2260-1, (2004)]

Chiral recognition between lactic acid derivatives and an aromatic alcohol in a supersonic expansion: electronic and vibrational spectroscopy.

2006-02-28

[Phys. Chem. Chem. Phys. 8(8) , 1007-16, (2006)]

Enantiomer separation by complexation SFC on immobilized Chirasil-nickel and Chirasil-zinc.

2000-07-05

[J. Biochem. Biophys. Methods 43(1-3) , 223-40, (2000)]

Resolution and synthesis of (S)-1-(2-naphthyl)ethanol with immobilized pea protein: as a new biocatalyst.

1999-11-01

[Biosci. Biotechnol. Biochem. 63(11) , 1991-2, (1999)]

More Articles...